RevoDx Vancomycin Resistance qPCR Kit
Antibiotic resistance occurs when the germs no longer respond to the antibiotics designed to kill them. If these germs develop resistance to vancomycin, an antibiotic that is used to treat some drug-resistant infections, they become vancomycin-resistant enterococci (VRE). Vancomycin is active only with respect to Gram-positive bacteria.
Vancomycin forms an intricate network of hydrogen bonds with the d-Ala-d-Ala region of Lipid II, interfering with the peptidoglycan layer maturation process. Resistance to vancomycin involves degradation of this natural precursor and its replacement with d-Ala-d-lac or d-Ala-d-Ser alternatives to which vancomycin has low affinity.
RevoDx Vancomycin resistance qPCR Kit is a real-time PCR test intended for the qualitative detection of vanA gene and vanB gene in single tube in which human RNase P is simultaneously detected.
- Ready-to-use kit
- Compatible with most real-time PCR detection systems with the channels FAM and HEX
- Human RNase P as an internal control
- The Limit of Detection (LoD) value is 91 copies/mL
- No cross-reactivity with the potential cross-reactive markers shown using both in silico analysis and wet testing.
- CE-IVD marked